George is a young addict who makes a living seeking covert information for Judith, the weary but wise New Orleans vampire hunter. Ready for change, George plans to score one final job so he can leave town, but finds the road to salvation quickly crumbling when his contacts start turning up dead.

Just hours after turning in his badge, Detective Nick Maguire learns that his sister Sara, a nurse at the local penitentiary, disappeared during a mysterious prison break. Nick ignores the wishes of his former partner, Gina, and begins to search for Sara himself.

A group of college kids and a younger brother are driving on an unfamiliar road. But this desolate road was built on an ancient Indian burial ground that is cursed. Out of nowhere, the group is attacked by a squirrel... a zombie squirrel brought back to life by the curse.